Oneonta outscored the Lady Eagles 16-5 in the first quarter and they never recovered, going into the locker room at the half down 26-14.
Angel Kidd was the only Lady Eagle in double figures. Kidd had 22 points and was 8-9 from the foul line.
Virginia Poe had nine points for Jacksonville followed by Dasia Kirksey with five and Destiny Easley and Ataliya Morgan each contributed two points.
Friday night was a much better game for Jacksonville as they built on a 32-25 lead at the half winning 65-47 over Etowah.
Kidd once again had the hot hand for Jacksonville scoring 29 points, hitting 2-for-2 from beyond the arc and was 7-for-10 from the foul line.
Poe was also in double figures with 20 points.
Sierra Stone added seven points for Jacksonville with Kirksey getting five and Darrien Martin four.